Laminin beta-2 Proteins

Protein Information

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.

Synonyms

AW211941; Lamb2; Lamb-2; Laminin B1s chain; Laminin chain B3; laminin chain beta 2; laminin S; laminin subunit beta 2; laminin subunit beta-2; laminin, beta 2; laminin, beta 2 (laminin S); laminin-11 subunit beta; Laminin-14 subunit beta; laminin-15 subunit beta; Laminin-3 subunit beta; laminin-4 subunit beta; Laminin-7 subunit beta; laminin-9 subunit beta; LAMS; NPHS5; npht; SLAM; S-LAM beta; S-laminin subunit beta